AOD 9604 – 5 mg Vial

AOD 9604 (Advanced Obesity Drug 9604) is a synthetic peptide analog derived from the C-terminal fragment (amino acids 177–191) of human growth hormone (hGH), enhanced with a tyrosine residue for improved biological stability. Initially developed as an anti-obesity agent, AOD 9604 is designed to promote fat metabolism without influencing blood glucose levels, IGF-1 production, or lean muscle growth—offering the lipolytic benefits of hGH with significantly reduced risk of hormonal side effects.

Though not approved for therapeutic use, AOD 9604 remains an active product in scientific research for its role in metabolic regulation, joint health, and fat reduction.

Its amino acid sequence is: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly

The approximate molecular formula for AOD 9604 is: C₇₈H₁₂₃N₂₃O₂₃S₂

Molecular Weight: ~1815.1 g/mol (monoisotopic mass 1813.8604 Daltons (Da)

• Peptide Composition: 15-amino-acid sequence (Tyr-hGH 177–191), structurally modified for enhanced stability via a disulfide bridge
• Purity: ≥ 98% (confirmed via MS-UPLC and HPLC; varies by supplier)
• Form: Lyophilized powder or gel; requires reconstitution with bacteriostatic water
• CAS Registry Number: 38624-39-7
• Molecular Action: Selectively targets adipose tissue to stimulate fat breakdown (lipolysis) and inhibit fat storage (lipogenesis)
• Intended Use: For laboratory and scientific research only. Not for human or animal consumption or therapeutic use

AOD 9604 acts primarily on adipocytes, promoting lipolysis and reducing adipogenesis. Research suggests that it may interact with β3-adrenergic receptors on fat cells, enhancing metabolic rate and fatty acid oxidation. Importantly, unlike full-length HGH, AOD 9604 does not elevate IGF-1 levels or impact insulin sensitivity, making it a safer research candidate in metabolic studies.

• In obese animal models (e.g., Zucker rats), AOD 9604 reduced body weight gain by over 50% within 19 days (oral, 500 µg/kg daily).
• Human clinical trials reported an average weight loss of 2.6 kg over 12 weeks versus 0.8 kg in placebo groups.

• Studies in rabbit osteoarthritis models indicate potential for cartilage regeneration and improved joint integrity.

• Ongoing research explores benefits in lipid profiles and metabolic syndrome, with no adverse impact on glucose regulation.

• Preliminary findings suggest possible cardiovascular benefits, though mechanisms remain under investigation.

• Targets stubborn fat areas
• Minimal impact on blood sugar levels
• Accelerates metabolism for enhanced fat-burning
• Potential benefits for bone health, including osteoarthritis and osteoporosis
• Most effective when combined with a balanced diet and regular exercise

• Method: Subcutaneous injection (under the skin)
• Site: Commonly in the lower abdomen or thigh
• Preparation:
  • Reconstitute vial with bacteriostatic water (per supplier instructions)
  • Gently swirl to mix; do not shake
  • Use sterile insulin syringe for accurate dosing

• Suggested Time: In the morning, on an empty stomach, before any food intake
• Rationale: Mimics natural metabolic cycles and may enhance fat metabolism based on animal and early human trials

• 300 mcg (0.3 mg) per day, subcutaneously. but it’s crucial to consult with a healthcare professional for personalized advice.

• Animal toxicology studies (rats, pigs, monkeys) show no genotoxicity (per Ames, chromosomal aberration, and micronucleus assays).

• Demonstrated a safety profile similar to placebo
• No detectable antibody formation or disturbances in carbohydrate metabolism

• AOD 9604 has been designated Generally Recognized As Safe (GRAS) for certain food-related applications by an expert panel, but is not FDA-approved for medical or dietary use.

• Stable at room temperature for up to 2 months. For long-term storage, keep below -18°C in a desiccated environment.

• Store at 4°C; do not freeze once mixed.

• Reconstitute with sterile bacteriostatic water. For laboratory use only.

• Must be handled in compliance with institutional research protocols by trained professionals.

AOD 9604 is intended strictly for in vitro laboratory research. It is not approved by the FDA or other regulatory bodies for medical, cosmetic, or dietary use. This product is not a drug, supplement, or therapeutic agent, and should not be used for human or veterinary consumption. Purchase and use should be limited to licensed laboratories or qualified research institutions. Always verify third-party purity testing and source materials from reputable suppliers.