NAD+ 1000 mg Liposomal Supplement – High-Potency Cellular Energy, Anti-Aging, and Optimal Wellness Formula

Nicotinamide Adenine Dinucleotide (NAD⁺) is a ubiquitous coenzyme found in all living cells. It serves as an essential redox cofactor and substrate in cellular metabolism, mitochondrial energy production, DNA repair, gene expression, and signaling pathways. Declining NAD⁺ levels have been widely studied in models of aging, oxidative stress, and metabolic dysfunction. Research with NAD⁺ has focused on its ability to sustain mitochondrial ATP production, maintain genomic stability, and regulate protein families such as sirtuins and PARPs.

• Enhanced Energy Production: NAD+ is a cornerstone of cellular metabolism, facilitating the conversion of nutrients into adenosine triphosphate (ATP), the body’s primary energy source. Supplementing with NAD+ can help combat fatigue and sustain energy levels throughout the day.
• Supports Healthy Aging: NAD+ activates sirtuins, a family of proteins linked to longevity, DNA repair, and cellular stress resistance. By supporting these processes, NAD+ may help mitigate age-related decline and promote vitality.
• Improves Cognitive Function: NAD+ supports neuronal health by enhancing synaptic plasticity and protecting against oxidative stress, potentially improving memory, focus, and mental clarity.
• Promotes Metabolic Health: Emerging research indicates NAD+ may improve insulin sensitivity, support fat metabolism, and aid in maintaining healthy blood sugar levels, making it a valuable tool for metabolic wellness.
• Facilitates DNA Repair: NAD+ is a critical cofactor for enzymes like PARPs (poly ADP-ribose polymerases), which repair damaged DNA, helping to maintain genomic stability and cellular health.
• Supports Cardiovascular Health: NAD+ may enhance vascular function and reduce oxidative stress in blood vessels, contributing to heart health.

Boosts Immune Function: By supporting cellular signaling pathways, NAD+ helps maintain a robust immune response, aiding the body’s ability to fight infections and inflammation.

• Energy Metabolism: In vitro and animal studies consistently demonstrate NAD⁺’s role in mitochondrial bioenergetics and ATP synthesis (Ying, 2008).
• DNA Repair: Research shows NAD⁺ depletion compromises DNA repair capacity through impaired PARP activity (Bai et al., 2011).
• Sirtuin Pathways: Studies demonstrate NAD⁺ is essential for sirtuin-mediated regulation of gene expression, inflammation, and cellular lifespan (Cantó et al., 2015).
• Animal Models: NAD⁺ supplementation has been shown to mitigate oxidative stress and improve metabolic function in rodent models (Zhang et al., 2016).
• Human Studies: Early clinical research indicates NAD⁺ administration can influence markers of energy metabolism, mitochondrial function, and systemic wellness (Brunet & Cantó, 2019; Grant et al., 2019). While further investigation is required, these findings highlight its potential relevance in metabolic and aging research.

NAD+ is supported by extensive research:

• Energy Metabolism: NAD+ is a critical coenzyme in the Krebs cycle and oxidative phosphorylation, processes that generate ATP (Nature Reviews Molecular Cell Biology, 2016).
• DNA Repair: NAD+ is a substrate for PARPs, which repair DNA damage, reducing the risk of mutations (Cell Metabolism, 2018).
• Sirtuin Activation: NAD+ fuels sirtuins (SIRT1-SIRT7), which regulate longevity, inflammation, and cellular stress response (Aging Cell, 2020).
• Clinical Studies: Human trials show NAD+ supplementation (500-1000mg daily) improves energy, cognitive function, and metabolic markers with minimal side effects (Journal of Clinical Investigation, 2021).

Direct NAD+ vs. Precursors: Unlike precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), direct NAD+ supplementation avoids conversion inefficiencies, delivering immediate bioavailability (Frontiers in Aging, 2022).

This compound is provided for Research Use Only (RUO). It is not intended for human or veterinary use. Handling should be performed with appropriate laboratory protective equipment.

• Reconstitution: NAD⁺ is soluble in water and most aqueous buffers.
• Storage (lyophilized): –20°C, protected from light and moisture.
• Storage (reconstituted): Aliquoted and stored at –80°C to prevent repeated freeze-thaw cycles.
• Stability: Lyophilized NAD⁺ is stable for up to 24 months under proper storage conditions.

NAD⁺ has been extensively studied in the following research contexts:
• Mitochondrial bioenergetics and ATP production.
• Oxidative stress and redox biology.
• DNA damage response and repair mechanisms.
• Aging models and cellular senescence.
• Metabolic health and insulin sensitivity models.
• Neurobiology and synaptic plasticity.
• Immune cell function and signaling.

These applications remain an active area of study for understanding the systemic role of NAD⁺ in biology.

Q: What form is this NAD⁺ supplied in?
A: Each vial contains 1000 mg NAD⁺ in lyophilized powder form with ≥99% purity.

Q: How should NAD⁺ be stored?
A: Lyophilized NAD⁺ should be stored at –20°C, protected from light. Once reconstituted, aliquot and store at –80°C.

Q: What research models use NAD⁺?
A: NAD⁺ is widely used in studies of cellular metabolism, DNA repair, mitochondrial function, and oxidative stress.

Q: Is this product intended for human use?
A: No. This product is for Research Use Only (RUO) and is not approved for human or veterinary applications.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Dietary supplements are regulated under the Dietary Supplement Health and Education Act (DSHEA) and are not classified as drugs. Individual results may vary. Always consult a healthcare professional before starting any new supplement, especially if you have medical conditions or are taking medications.