SNAP-8 10mg – Peptide Vial

SNAP-8, scientifically known as Acetyl Octapeptide-3 or Acetyl Glutamyl Heptapeptide-1, is a premium-grade synthetic octapeptide designed exclusively for in vitro laboratory research. Comprising eight amino acids, SNAP-8 is an extended analog of the hexapeptide Argireline (Acetyl Hexapeptide-8), offering enhanced potential in studies focused on anti-aging mechanisms, skin rejuvenation, and neuromuscular modulation. With a molecular weight of 1075.18 g/mol and a purity of ≥98%, SNAP-8 is synthesized in state-of-the-art cGMP-compliant facilities to ensure unparalleled consistency, reliability, and precision for researchers. Each vial contains 10mg of lyophilized SNAP-8 powder, providing a stable and versatile tool for controlled scientific experimentation in fields such as cosmetic science, dermatology, and neurobiology.

• Chemical Name: Acetyl Glutamyl Heptapeptide-1 (Acetyl Octapeptide-3)
• Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
• Molecular Formula: C41H70N16O16S
• Molecular Weight: 1075.18 g/mol
• CAS Number: 868844-74-0
• PubChem CID: 76283482
• Appearance: White to off-white lyophilized powder
• Purity: ≥98% (verified by HPLC and mass spectrometry)
• Solubility: Highly soluble in bacteriostatic water or sterile saline for reconstitution

Stability: Lyophilized form stable at -20°C for up to 18 months; reconstituted peptide stable at 4°C for up to 2 weeks

SNAP-8 functions by mimicking the N-terminal end of SNAP-25, a critical protein in the SNARE (Soluble NSF Attachment Protein Receptor) complex, which mediates vesicle fusion and neurotransmitter release in neuromuscular signaling. By competing with SNAP-25, SNAP-8 destabilizes the SNARE complex, reducing the efficiency of neurotransmitter release and attenuating muscle contractions. This mechanism makes SNAP-8 a valuable tool for studying muscle relaxation pathways and their applications in wrinkle reduction and skin rejuvenation. In vitro studies have demonstrated that SNAP-8’s interference with SNARE complex formation offers a non-invasive alternative to botulinum toxin, enabling researchers to explore similar effects without the risks associated with invasive treatments.

SNAP-8 is a versatile peptide widely used in laboratory settings for the following research purposes:

• Anti-Wrinkle and Anti-Aging Studies: SNAP-8 is extensively studied for its ability to reduce the depth of expression lines and wrinkles caused by repetitive facial muscle contractions, particularly around the eyes (crow’s feet) and forehead. In a notable in vitro study, a 10% SNAP-8 formulation applied twice daily resulted in a maximum wrinkle depth reduction of 62% and an average reduction of 35% over 28 days, as measured by silicon imprint analysis.
• Skin Rejuvenation and Collagen Synthesis: Preclinical animal studies suggest SNAP-8 may enhance type 1 collagen production, a critical structural protein in the dermis, improving skin elasticity and firmness. This makes it a key candidate for research into skin aging and tissue regeneration.
• Neuromuscular Modulation: SNAP-8’s interaction with the SNARE complex provides a model for studying neurotransmitter release and muscle contraction mechanisms, with applications in neurobiology and muscle physiology research.
• Cosmetic Formulation Development: SNAP-8 is frequently incorporated into topical formulations (e.g., creams, gels, serums) at concentrations of 3-10% to investigate its efficacy as an anti-aging agent. Its stability in various delivery systems makes it ideal for developing novel cosmetic products.
• Comparative Studies: Researchers use SNAP-8 to compare its efficacy against other peptides like Argireline, with studies indicating SNAP-8 may be up to 30% more effective in reducing wrinkle depth due to its extended peptide chain.

• Form: Lyophilized powder in a sterile, vacuum-sealed glass vial
• Quantity: 10mg per vial
• Purity: ≥98%, confirmed by third-party high-performance liquid chromatography (HPLC) and mass spectrometry
• Endotoxin Levels: <0.1 EU/μg (suitable for sensitive in vitro applications)
• Heavy Metals: Below detectable limits, ensuring safety for laboratory use
• Packaging: Sealed in a 2mL or 5mL glass vial with a rubber stopper and aluminum cap, protected in a temperature-controlled environment during transport
• Storage Conditions:
  • Lyophilized: Store at -20°C for long-term stability (up to 18 months). For short-term storage (up to 2 months), room temperature (15-25°C) is acceptable if kept in a dry, dark environment.
  • Reconstituted: Store at 4°C and use within 14 days to prevent degradation. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
• Solubility: Soluble in bacteriostatic water (0.9% sodium chloride with 0.9% benzyl alcohol) or sterile saline. Avoid using distilled water alone, as it may reduce peptide stability.

SNAP-8 is intended solely for in vitro laboratory research and is not approved for human or veterinary use. Researchers should adhere to the following protocols:

• Reconstitution: Add 1mL of bacteriostatic water to the vial using a sterile syringe. Allow the powder to dissolve naturally without shaking to preserve peptide structure. The resulting solution will have a concentration of 10mg/mL.
• Formulation for Topical Studies: For anti-wrinkle or skin rejuvenation experiments, mix reconstituted SNAP-8 into a non-scented cream, gel, or serum to achieve a final concentration of 3-10%. A 10% concentration is recommended for maximum efficacy in wrinkle reduction studies. Apply to the target area as per experimental design.
• Handling Precautions: Only trained, licensed professionals should handle SNAP-8. Use sterile equipment and follow biosafety protocols to prevent contamination. Avoid direct skin contact, inhalation, or ingestion, as the peptide is not approved for human use.
• Dosage Considerations: Dosage varies by experiment. In topical studies, a 3-10% SNAP-8 solution applied twice daily is common. For in vitro cellular studies, concentrations typically range from 1-100 μM, depending on the cell line and research objectives.

Safety Notes: Wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Dispose of unused peptide and contaminated materials according to local biohazard regulations.

• Enhanced Efficacy: In vitro and preclinical studies demonstrate that SNAP-8 outperforms Argireline by up to 30% in reducing wrinkle depth, attributed to its longer peptide chain and stronger SNARE complex inhibition.
• Non-Invasive Model: SNAP-8 provides a safer, non-invasive alternative to botulinum toxin for studying muscle relaxation and anti-aging effects, ideal for topical formulation research.
• Collagen Synthesis: Animal studies indicate SNAP-8 may stimulate type 1 collagen production, supporting investigations into skin firmness and elasticity.
• Versatile Applications: Its stability in various formulations (emulsions, gels, serums) makes SNAP-8 suitable for diverse experimental setups, from cell culture to topical delivery systems.
• No Significant Toxicity: In vitro studies report no significant cytotoxicity or adverse effects at recommended concentrations, ensuring safety for controlled research.

SNAP-8 is synthesized using solid-phase peptide synthesis (SPPS) and purified via reverse-phase HPLC to achieve ≥98% purity. Each batch undergoes rigorous third-party testing, including:

• HPLC Analysis: Confirms peptide purity and composition.
• Mass Spectrometry: Verifies molecular weight and sequence accuracy.
• Endotoxin Testing: Ensures levels are below 0.1 EU/μg for safe in vitro use.
• Heavy Metal Screening: Confirms absence of contaminants like lead, mercury, or arsenic.
  Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS) are available upon request from reputable suppliers to verify product quality and safety.

SNAP-8 is sold exclusively for scientific research purposes and is not intended for human or animal consumption. It is not approved by the FDA or any other regulatory body to diagnose, treat, cure, or prevent any medical condition. Bodily introduction into humans or animals is strictly prohibited by law. By purchasing SNAP-8, the buyer acknowledges the risks associated with handling research chemicals and agrees to use the product solely for in vitro studies. Researchers must comply with all applicable local, national, and institutional regulations governing the use of research peptides.

• Lyophilized Powder: Store at -20°C for up to 18 months. For short-term storage (up to 2 months), keep at room temperature (15-25°C) in a dry, dark place. Avoid exposure to moisture, heat, or direct sunlight.
• Reconstituted Solution: Store at 4°C and use within 14 days. Do not freeze reconstituted peptide, as this may cause degradation. Use sterile techniques to prevent microbial contamination.
• Shelf Life: Lyophilized SNAP-8 remains stable for 18 months under recommended conditions. Check supplier’s batch-specific expiration date for accuracy.

While SNAP-8 is not intended for human use, in vitro studies report no significant cytotoxicity at recommended concentrations. However, researchers should be aware of potential risks in experimental settings:

• Contamination: Improper handling or non-sterile reconstitution may introduce microbial contamination, affecting experimental outcomes.
• Stability Issues: Prolonged exposure to heat, light, or repeated freeze-thaw cycles may reduce peptide efficacy.
• Allergic Reactions: Although rare in laboratory settings, researchers with peptide sensitivities should exercise caution and wear PPE.

SNAP-8 is a cutting-edge research peptide that combines high purity, stability, and versatility for advanced scientific studies. Its ability to modulate SNARE complex activity, reduce wrinkle depth, and promote collagen synthesis makes it an indispensable tool for researchers in cosmetic science, dermatology, and neurobiology. With proven efficacy, rigorous quality control, and compatibility with various experimental systems, SNAP-8 empowers scientists to push the boundaries of anti-aging and neuromuscular research.

SNAP-8 10mg is the gold standard for researchers exploring anti-aging, skin rejuvenation, and neuromuscular pathways. Its high purity, robust stability, and well-documented efficacy in laboratory settings make it an essential tool for cutting-edge scientific discovery. Order from us today and unlock the potential of SNAP-8 for your research endeavors!