Selank 10mg

Selank 10mg is a premium-grade, lyophilized synthetic heptapeptide designed exclusively for advanced scientific research and in vitro laboratory applications. Chemically known as Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP), Selank is a synthetic analogue of the endogenous immunomodulatory peptide tuftsin, with an extended C-terminus (Pro-Gly-Pro) to enhance its metabolic stability and prolong its half-life. This peptide is meticulously synthesized to achieve ≥99% purity, making it an ideal tool for researchers investigating neuromodulation, anxiolytic mechanisms, cognitive enhancement, and immunomodulatory pathways. Selank 10mg is strictly intended for use by qualified professionals in controlled laboratory settings and is not approved for human or animal consumption under any circumstances.

• Chemical Name: Selank (Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2).
• Molecular Formula: C33H57N11O9.
• Molecular Weight: 787.9 g/mol.
• Appearance: White to off-white lyophilized powder.
• Solubility: Soluble in sterile water, bacteriostatic water, or saline solution for reconstitution.
• Purity: ≥99%, confirmed via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).
• Sequence: Threonine-Lysine-Proline-Arginine-Proline-Glycine-Proline (Thr-Lys-Pro-Arg-Pro-Gly-Pro).
• CAS Number: 129954-34-3.
• Form: Supplied as a lyophilized powder in a sterile, 3 mL glass vial containing 10 mg of Selank.

• Packaging: Each vial contains 10 mg of Selank, sealed under vacuum in a 3 mL sterile glass vial to ensure stability and prevent contamination. Vials are free of mannitol or other fillers to maintain maximum purity.
• Storage Conditions:
  • Lyophilized Form: Store at 2–8°C (refrigerated) in a cool, dry, dark environment. Avoid exposure to heat, moisture, or direct sunlight. Stable for up to 2 years when stored properly.
  • Reconstituted Form: After reconstitution with bacteriostatic water, store at 2–8°C and use within 30 days to maintain peptide integrity. Do not freeze reconstituted solutions, as this may degrade the peptide.

Selank 10mg is a versatile peptide for in vitro and preclinical research, offering insights into several physiological and neurological processes. Key research applications include:

• Neuromodulation:
  • Modulates neurotransmitter systems, including GABA, serotonin, and dopamine, by influencing gene expression and receptor activity.
  • Investigates the role of enkephalin-degrading enzymes, potentially increasing endogenous enkephalin levels, which are critical for pain modulation and stress responses.
• Anxiolytic Effects:
  • Exhibits non-sedative anxiolytic properties in preclinical models, comparable to low-dose benzodiazepines but without side effects like sedation, amnesia, or dependence.
  • Studies suggest efficacy in models of generalized anxiety disorder (GAD), social anxiety, and stress-induced anxiety.
• Cognitive Enhancement:
  • Enhances memory, learning, and attention in animal models, potentially through upregulation of brain-derived neurotrophic factor (BDNF) in the hippocampus.
  • Investigates nootropic effects, including improved focus, mental clarity, and cognitive resilience under stress.
• Immunomodulation:
  • As a tuftsin analogue, Selank modulates Interleukin-6 (IL-6) expression and balances T helper cell cytokines, offering potential for studying immune system regulation.
  • Explores anti-inflammatory pathways and immune response optimization in infection or stress models.
• Neuroprotection:
  • Inhibits enkephalin degradation, potentially enhancing opioid peptide activity, which may influence mood, pain perception, and stress resilience.
  • Investigates neuroprotective effects in models of neurodegeneration or oxidative stress.
• Antidepressant Potential:
  • Modulates serotonin metabolism and IL-6 expression in models of depression, providing a tool for studying mood disorder mechanisms.
• Stress Response:
  • Reduces stress-induced physiological and behavioral changes in preclinical models, offering insights into hypothalamic-pituitary-adrenal (HPA) axis regulation.

Selank’s multifaceted effects stem from its interactions with multiple biological systems:

• GABAergic System: Enhances GABA receptor sensitivity, contributing to anxiolytic and calming effects without sedation.
• Serotonergic System: Increases serotonin metabolism in key brain regions (e.g., hippocampus, prefrontal cortex), supporting mood stabilization and cognitive function.
• BDNF Upregulation: Stimulates brain-derived neurotrophic factor expression, promoting neuroplasticity and cognitive resilience.
• Enkephalin Preservation: Inhibits enzymes that degrade enkephalins, potentially increasing endogenous opioid activity for pain and mood regulation.
• Immune Modulation: Influences cytokine production (e.g., IL-6) and immune cell activity, supporting research into inflammation and immune balance.

• Reconstitution Instructions:
  1. Use a sterile syringe to draw 3.0 mL of bacteriostatic water (0წ System: 0.9% sodium chloride) or sterile water.
  2. Slowly inject the solution along the inner wall of the vial to avoid foaming.
  3. Gently swirl (do not shake) until the powder is fully dissolved.
  4. Label the vial with the date and concentration (e.g., 3.33 mg/mL for 3 mL reconstitution).
  5. Store at 2–8°C and use within 30 days.

• Concentration: Reconstituting with 3 mL of bacteriostatic water yields a concentration of approximately 3.33 mg/mL (3,333 mcg/mL).
• Handling Precautions:
  • Use sterile insulin syringes for precise measurement in experimental setups.
  • Avoid vigorous shaking to prevent peptide degradation.
  • Handle with sterile gloves and follow laboratory safety protocols to prevent contamination.

Preclinical studies have highlighted several potential benefits of Selank, making it a valuable research tool:

• Anxiety Reduction: Demonstrates rapid anxiolytic effects in animal models, reducing stress-related behaviors without sedation or cognitive impairment.
• Cognitive Improvement: Enhances memory consolidation, recall, and attention, potentially via BDNF upregulation and improved synaptic plasticity.
• Mood Regulation: Suppresses IL-6 and modulates serotonin, showing promise in models of depression and mood instability.
• Immunomodulatory Effects: Balances cytokine production and enhances immune responses, useful for studying inflammation and immune dysregulation.
• Neuroprotection: Protects neurons from oxidative stress and supports enkephalin activity, aiding research into neurodegenerative conditions.
• Minimal Side Effects: Studies report low toxicity, with rare instances of mild dizziness or gastrointestinal discomfort in experimental models, and no evidence of dependence or withdrawal.

• Research-Only Use: Selank 10mg is strictly for in vitro and preclinical research. It is not approved by the FDA or any regulatory body for human or animal use, and bodily introduction is prohibited by law.
• Regulatory Compliance: Researchers must adhere to local, national, and international regulations governing peptide research, including ethical guidelines for animal or cellular studies.
• Stability Concerns: Improper storage (e.g., exposure to heat or freezing reconstituted solutions) may degrade the peptide, affecting research outcomes.
• Limited Clinical Data: While preclinical studies are promising, Selank’s effects in humans are not fully established, limiting its scope to laboratory research.
• Allergen Warning: Although rare, some research models may exhibit hypersensitivity to peptide components; monitor closely during experiments.

Selank 10mg is manufactured in state-of-the-art facilities compliant with Good Manufacturing Practices (GMP). Each batch undergoes rigorous quality control, including:

• HPLC Testing: Ensures ≥99% purity by analyzing peptide composition.
• Mass Spectrometry: Confirms molecular weight and structural integrity.
• Microbiological Testing: Verifies the absence of bacterial, fungal, or other contaminants.
• Third-Party Validation: Independent laboratories confirm purity and quality to ensure reliability for research purposes.

• Intended Use: Exclusively for in vitro laboratory research by qualified professionals. Not for use as a drug, supplement, or cosmetic.
• Safety Protocols:
  • Use in a controlled laboratory environment with proper ventilation and sterile equipment.
  • Dispose of unused or expired product in accordance with local biohazard regulations.
  • Avoid contact with skin, eyes, or mucous membranes during handling.
• Legal Disclaimer: Researchers are responsible for ensuring compliance with all applicable laws, including those related to peptide handling, storage, and experimentation. Misuse, including human or animal administration, is strictly forbidden.

• Shelf Life: Lyophilized Selank remains stable for up to 2 years when stored at 2–8°C. Reconstituted solutions are stable for 30 days under proper conditions.
• Batch Consistency: Each batch is assigned a unique lot number for traceability, ensuring consistency across experiments.
• Research Considerations:
  • Researchers should design experiments with appropriate controls to isolate Selank’s effects.
  • Consult research teams for optimal dosing protocols in specific research models (e.g., 100–500 mcg/kg in animal studies).
  • Monitor environmental conditions (e.g., temperature, humidity) during experiments to prevent peptide degradation.
• Ethical Guidelines: Adhere to institutional review board (IRB) or ethics committee guidelines for research involving animal or cellular models.

Selank 10mg is provided solely for scientific research and development purposes. It is not intended for human or animal consumption, medical treatment, or diagnostic use. All information provided is for educational and research purposes only. Researchers assume full responsibility for ensuring compliance with all applicable laws and regulations. The supplier is not liable for misuse, improper storage, or unauthorized use of the product. Bodily introduction into humans or animals is strictly prohibited by law.